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¹ Cytopatholgy Division, Tohkai Cytopathology Institute, Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-uzura, Gifu 500-8285, Japan ² Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan

Received: 5 April 2012; in revised form: 14 June 2012 / Accepted: 6 July 2012 / Published: 16 July 2012

Abstract: Inflammation is involved in all stages of carcinogenesis. Inflammatory bowel disease, such as ulcerative colitis and Crohn?s disease is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer (CRC). Several molecular events involved in chronic inflammatory process are reported to contribute to multi-step carcinogenesis of CRC in the inflamed colon. They include over-production of free radicals, reactive oxygen and nitrogen species, up-regulation of inflammatory enzymes in arachidonic acid biosynthesis pathway, up-regulation of certain cytokines, and intestinal immune system dysfunction. In this article, firstly I briefly introduce our experimental animal models where colorectal neoplasms rapidly develop in the inflamed colorectum. Secondary, data on preclinical cancer chemoprevention studies of inflammation-associated colon carcinogenesis by morin, bezafibrate, and valproic acid, using this novel inflammation-related colorectal carcinogenesis model is described.

Keywords: inflammatory bowel disease; colorectal cancer; chemoprevention; animal model; AOM; DSS; morin; bezafibrate; valproic acid

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Cite This Article

MDPI and ACS Style

Tanaka, T. Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis. Cancers 2012, 4, 673-700.

AMA Style

Tanaka T. Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis. Cancers. 2012; 4(3):673-700.

Chicago/Turabian Style

Tanaka, Takuji. 2012. "Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis." Cancers 4, no. 3: 673-700.

Source: http://www.mdpi.com/2072-6694/4/3/673

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